Hot selling Cialis CAS Number171596-29-5 CAS NO.171596-29-5

1.Fast and safety delivery by well-reputed shipping line;

2.we have our own chemical laboratory and factory

3.Reasonable price, excellent quality and attentive service.

4.prompt reply.we can reply your inquiry within 12 hours.

5.sample free(depends on product,we just collect courier fee, or give us your express account NO.)

6.Rich experience in loading a great amount of containers

7.Sperior quality and good package

8.Fast and safety delivery by well-reputed shipping line

Use of Cialis

Tadalafil is a PDE5 inhibitor with an IC50 value of 1.8 nM.IC50 Value: 1.8±0.4nM [1]Target: PDE 5Tadalafil is marketed in pill form for treating erectile dysfunction(ED) under the name Cialis, and under the name Adcirca for the treatment of pulmonary arterial hypertension. Tadalafil can elevate the level of cGMP in the corpus cavernosum and effectively improve ED of various causes and degrees.in vitro: Biochemical potencies (affinities) of these compounds for PDE5 determined by IC(50), K(D) (isotherm), K(D) (dissociation rate), and K(D) ((1/2) EC(50)), respectively, were the following: sildenafil (3.7 +/- 1.4, 4.8 +/- 0.80, 3.7 +/- 0.29, and 11.7 +/- 0.70 nM), tadalafil (1.8 +/- 0.40, 2.4 +/- 0.60, 1.9 +/- 0.37, and 2.7 +/- 0.25 nM); and vardenafil (0.091 +/- 0.031, 0.38 +/- 0.07, 0.27 +/- 0.01, and 0.42 +/- 0.10 nM). Thus, absolute potency values were similar for each inhibitor, and relative potencies were vardenafil >> tadalafil > sildenafil [1]. 0.5 ml tadalafil solutions with different concentrations were added (0.2, 0.1, 0.05 and 0.025 μg ml-1, respectively) into semen samples. In both groups, samples treated with 0.2 μg ml-1 tadalafil had significant increase in sperm motility after 2 h incubation [2].in vivo: The Tadalafil-treated group showed enhanced erectile function (intracavernosal pressure/mean arterial pressure) at 0.3, 0.5, 1, 3, and 5 Hz compared with diabetic group values at the respective frequencies (P <.05) that approached control values [3]. oral administration of tadalafil (20 mg) or sildenafil (100 mg) was given. In both groups, computer-assisted semen analysis parameters showed no significant difference. After the administration of tadalafil (2 h) and sildenafil (1 h), there was no significant difference observed in premature acrosome reaction incidence rate [2].Clinical trial: Study the Safety and Effectiveness of Tadalafil in Men With Problems Getting or Maintaining an Erection When Taken Prior to Desiring an Erection. Phase 3

Synonyms

We are a manufacturer and trader in China, with 10 years of experience in the export of chemical and pharmaceutical raw materials and 320 employees. We are all promoted on  Made in China,Lookchem chemical book, Google platform.
More than ten years of export experience Specializing in the production of pharmaceutical raw materials, odybuilding products, sexual enhancement products, local anesthesia products, best-selling pharmaceutical intermediates, etc. The quality of our products has reached the international leading level. Can provide free samples to provide testing. Provide product customization services.
   We have overseas warehouses in California, New Laredo Mexico, Vancouver Canada, Amsterdam Netherlands, and Melbourne Australia. Overseas warehouses can provide some of the best-selling products. We look forward to the cooperation of local powerful distributors and factories. Deliver the package as soon as possible.
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